The learning objectives of the Surgical Pathology Demonstration on Friday 4th November for UCL 2nd Year SSC Medical Students were the following

1 .Review classical examples of inflammatory and neoplastic conditions of the large bowel

2. Compare and contrast specific types of inflammatory condition of the of the large bowel

3. Relate some macroscopic appearances to microscopic changes.

Macro examples shown included cases of

Crohns Disease and Ulcerative Colitis (Inflammatory Bowel Disease – IBD )

  • Including Pan Colitis of Ulcerative Colitis
  • Ileo-caecal Crohn’s disease
  • Inflammatory polyposis in IBD including Giant Polyposis (rare)
  • Strictures and Fistulas in Crohn’s Disease

Ischaemic small bowel

  • Eg Volvulus (not shown), Small bowel Embolus, Incarcerated (strangulated)hernia, Intussusception of terminal ileum into caecum

Pseudomembranous Colitis   (please review typical histology at pathweb).

Diverticular Disease with severe Diverticulitis and Abscess formation

Polyps of the large bowel  (Hyperplastic Polyp, Tubular Adenoma, Tubulovillous Adenoma and Villous Adenoma.

Carcinoma of the Colon (typical Radiology Apple Core deformity)


Some presenting symptoms and signs of IBD and Neoplasia of the Lower GI Tract

  • CIBH (diarrhoea, constipation), Melena

Increased risk of Dysplasia and Neoplasia in Chronic IBD.

Masses in the right iliac fossa (Quiz results to follow as an attachment)

Not discussed

other bacterial and viruses affecting the lower intestines ( but at some point you should look up)

Bacteria:  Clostridium Difficile (discussed) E Coli , Campylobacter, Shigella, Salmonella, Yersinia, Vibrio Cholera

Virus                Rotavirus, Norovirus  ,  Cytomegalovirus (discussed in context of superadded infection in IBD)

Protozoa          Entamoeba Histolyticum (Amoebiasis)

Infestations     Pinworm – Enterobius Vermicularis (Histology section of the appendix shown)

Note the topic for this weeks “Blog/Homework” is

Compare and contrast the conditions Crohn’s Disease and Ulcerative Colitis

This should be 250 – 400 words

Please restrict your blog to one of the following



Clinical presentations and clinical features

Pathology and complications

I will accept essay style or short notes.

No diagrams but include references to the text/articles/website used.

 to be sent back by Wednesday 9th November 5 pm ish